High-Affinity Arginine Transport of Bovine Aortic Endothelial Cells Is Impaired by Lysophosphatidylcholine
نویسندگان
چکیده
منابع مشابه
High-affinity arginine transport of bovine aortic endothelial cells is impaired by lysophosphatidylcholine.
The mechanisms of endothelial dysfunction characterized by the impaired nitric oxide (NO) release have not yet been clarified. Because the phenomenon is mimicked in vitro by the application of oxidized LDL and its major lipid constituent, lysophosphatidylcholine (LPC), we analyzed their effects on the arginine-NO system, especially on the arginine transport system. LPC inhibited NO release indu...
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Vascular endothelium, which produces endothelium-derived relaxing and constricting factors, plays an important role in regulating the vascular tone. We recently demonstrated that oxidized low density lipoprotein inhibited endothelium-dependent relaxation and that lysophosphatidylcholine accumulated during the oxidative modification of low density lipoprotein was the essential substance for the ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1998
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.83.11.1088